Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 6/20 | 0.32 |
| ▸ | ALPL | P05186 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20567149 | 0.74 | LMNA (0.40) | KMT2ALMNAALDH1A1CNR1CNR2 | |
| SCHEMBL28048741 | 0.73 | ALDH1A1 (0.54) | LMNAHTTALDH1A1GABRA1GABRG2 | |
| SCHEMBL20046201 | 0.70 | LMNA (0.55) | KMT2ALMNAATRGABRA1GABRG2 | |
| SCHEMBL30670211 | 0.70 | LMNA (0.55) | KMT2ALMNAATRGABRA1GABRG2 | |
| SCHEMBL7421480 | 0.69 | ALDH1A1 (0.41) | LMNAALDH1A1CNR1CNR2NPSR1 | |
| SCHEMBL27869406 | 0.67 | ALDH1A1 (0.40) | LMNAALDH1A1CNR1CNR2NPSR1 | |
| SCHEMBL30599569 | 0.66 | ALDH1A1 (0.47) | KMT2ALMNAMEN1ALDH1A1CNR1 | |
| SCHEMBL2210499 | 0.66 | ALDH1A1 (0.47) | KMT2ALMNAMEN1ALDH1A1CNR1 | |
| SCHEMBL1633849 | 0.66 | ALDH1A1 (0.40) | LMNAALDH1A1NPSR1GABRA1GABRG2 | |
| SCHEMBL38655809 | 0.66 | ALDH1A1 (0.43) | KMT2ALMNAMEN1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101374843-B | Triazolopyridazines as tyrosine kinase modulators | JANSSEN PHARMACEUTICA NV | 2012-09-05 | — | — | CN | disclosed |
| CN-101374843-A | Triazolopyridazines as tyrosine kinase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-25 | — | — | CN | disclosed |