Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 2/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14368730 | 1.00 | POLB (0.58) | POLBGAASMN1; SMN2LMNASIGMAR1 | |
| SCHEMBL14368694 | 0.90 | MCHR1 (0.52) | POLBSIGMAR1HRH3HPGDMAPT | |
| SCHEMBL28783269 | 0.90 | MCHR1 (0.52) | POLBSIGMAR1HRH3HPGDMAPT | |
| SCHEMBL14368746 | 0.88 | EPHX2 (0.56) | SMN1; SMN2SIGMAR1CCR3ALDH1A1 | |
| SCHEMBL28944413 | 0.88 | EPHX2 (0.56) | SMN1; SMN2SIGMAR1CCR3ALDH1A1 | |
| SCHEMBL14368687 | 0.85 | EPHX2 (0.60) | POLBLMNASIGMAR1HRH3HPGD | |
| SCHEMBL14392352 | 0.84 | CHRNA7 (0.51) | SMN1; SMN2MAPTTP53TSHRKDM4E | |
| SCHEMBL14368703 | 0.84 | CHRNA7 (0.51) | SMN1; SMN2MAPTTP53TSHRKDM4E | |
| SCHEMBL27757300 | 0.84 | CHRNA7 (0.51) | SMN1; SMN2MAPTTP53TSHRKDM4E | |
| SCHEMBL14368812 | 0.83 | LMNA (0.55) | LMNAHRH3HPGDMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | claimed |
| CN-101484442-A | Compounds that are agonists of muscarinic receptors and tha may be effective in treating pain, alzheimer's disease and/or schizophrenia | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | disclosed |