Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | PCSK9 | Q8NBP7 | 12/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27786378 | 0.89 | HRH3 (0.55) | HRH3KCNH2GPR119PTK2CACNA2D1 | |
| SCHEMBL3665747 | 0.85 | HRH3 (0.62) | HRH3KCNH2GPR119PCSK9 | |
| SCHEMBL3665742 | 0.85 | HRH3 (0.62) | HRH3KCNH2GPR119PCSK9 | |
| SCHEMBL3636321 | 0.78 | HRH3 (0.65) | HRH3KCNH2GPR119PTK2 | |
| Hydrochloric Acid SCHEMBL3639931 | 0.77 | HRH3 (0.64) | HRH3KCNH2GPR119PTK2 | |
| SCHEMBL18924338 | 0.76 | HRH3 (0.70) | HRH3KCNH2GPR119 | |
| Tert-Butyl Formate SCHEMBL27786382 | 0.75 | GPR119 (0.45) | GPR119 | |
| SCHEMBL3636580 | 0.74 | GPR119 (0.83) | HRH3KCNH2GPR119 | |
| SCHEMBL3670891 | 0.73 | HRH3 (0.88) | HRH3KCNH2GPR119 | |
| SCHEMBL4939821 | 0.72 | GPR119 (0.77) | HRH3KCNH2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778838-A | Azacyclylbenzamide derivatives as histamine-3 antagonists | WYETH CORP | 2010-07-14 | — | — | CN | disclosed |