Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 5/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467601 | 0.83 | FLT3 (0.36) | AXLKDRINSRALDH1A1LMNA | |
| SCHEMBL467580 | 0.79 | AXL (0.36) | AXLKDRINSR | |
| SCHEMBL18009413 | 0.79 | ALDH1A1 (0.46) | AXLALDH1A1LMNAMAPTMAPK1 | |
| SCHEMBL467696 | 0.78 | AXL (0.43) | AXLKDRINSRALDH1A1 | |
| SCHEMBL467792 | 0.77 | AXL (0.44) | HRH3AXLKDRINSR | |
| SCHEMBL467659 | 0.76 | AXL (0.49) | HRH3AXLKDRINSRALDH1A1 | |
| SCHEMBL467478 | 0.76 | AXL (0.42) | AXLKDRINSRALDH1A1MAPT | |
| SCHEMBL16271154 | 0.75 | AXL (0.41) | AXLKDR | |
| SCHEMBL16271153 | 0.75 | AXL (0.41) | AXLKDR | |
| SCHEMBL16271152 | 0.75 | AXL (0.41) | AXLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101622246-A | Polycyclic heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2010-01-06 | — | — | CN | claimed |
| CN-101622246-A | Polycyclic heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2010-01-06 | — | — | CN | disclosed |