Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 2/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27790975 | 0.86 | AXL (0.47) | AXLINSRKDR | |
| SCHEMBL30090809 | 0.86 | AXL (0.47) | AXLINSRKDR | |
| SCHEMBL467659 | 0.82 | AXL (0.49) | AXLINSRKDR | |
| SCHEMBL27790983 | 0.82 | AXL (0.38) | AXLINSRKDR | |
| SCHEMBL467833 | 0.82 | AXL (0.47) | AXLINSRKDR | |
| SCHEMBL467688 | 0.82 | AXL (0.40) | AXLINSRKDRKDM1A | |
| SCHEMBL467792 | 0.80 | AXL (0.44) | AXLINSRKDR | |
| SCHEMBL28784752 | 0.79 | HRH3 (0.39) | AXLINSRKDR | |
| SCHEMBL467696 | 0.77 | AXL (0.43) | AXLINSRKDR | |
| SCHEMBL467478 | 0.77 | AXL (0.42) | AXLINSRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |