Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18009413 | 0.89 | ALDH1A1 (0.46) | FLT3AXLALDH1A1L3MBTL1TTK | |
| SCHEMBL467696 | 0.88 | AXL (0.43) | AXLALDH1A1L3MBTL1KDRINSR | |
| SCHEMBL28784752 | 0.83 | HRH3 (0.39) | AXLALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL27791062 | 0.83 | CHRNB2 (0.32) | AXLTTKKDRINSR | |
| SCHEMBL467659 | 0.82 | AXL (0.49) | AXLALDH1A1L3MBTL1MAPTMAPK1 | |
| SCHEMBL467537 | 0.81 | CHIT1 (0.36) | AXLALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL27769791 | 0.81 | ALDH1A1 (0.37) | AXLALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL467478 | 0.81 | AXL (0.42) | AXLALDH1A1MAPTMAPK1KDM4E | |
| SCHEMBL28784754 | 0.80 | DRD2 (0.38) | MAPTGAA | |
| SCHEMBL13276198 | 0.80 | ADORA2A (0.40) | AXLALDH1A1MAPTMAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387395-A1 | AXL INHIBITORS FOR USE IN COMBINATION THERAPY FOR PREVENTING, TREATING OR MANAGING METASTATIC CANCER | Rigel Pharmaceuticals, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| US-8040491-B2 | Exposure method, substrate stage, exposure apparatus, and device manufacturing method | NIKON CORPORATION (JP) | 2011-10-18 | — | — | US | disclosed |