Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28785678 | 1.00 | P2RX7 (0.48) | P2RX7MRGPRX4NPSR1LMNASMN1; SMN2 | |
| SCHEMBL27776544 | 0.85 | P2RX7 (0.51) | P2RX7CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL27776543 | 0.85 | P2RX7 (0.51) | P2RX7CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL27797239 | 0.84 | P2RX7 (0.42) | P2RX7 | |
| SCHEMBL27797240 | 0.84 | P2RX7 (0.42) | P2RX7 | |
| SCHEMBL27776447 | 0.82 | P2RX7 (0.51) | P2RX7SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL27776449 | 0.82 | P2RX7 (0.51) | P2RX7SMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL27797214 | 0.82 | P2RX7 (0.46) | P2RX7ALDH1A1 | |
| SCHEMBL307176 | 0.80 | P2RX7 (0.55) | P2RX7LMNACYP1A2CYP2C19HSP90AA1 | |
| SCHEMBL8132956 | 0.79 | P2RX7 (0.46) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101686680-A | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC | 2010-03-31 | — | — | CN | claimed |
| CN-101686680-A | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC | 2010-03-31 | — | — | CN | disclosed |