Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GGT1 | P19440 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687227 | 0.91 | MAPK1 (0.41) | MAPK1PARP1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL7730049 | 0.79 | MAPT (0.44) | MAPK1KDM4EALDH1A1HSD17B10ESR1 | |
| SCHEMBL8052504 | 0.79 | MAPK1 (0.38) | MAPK1KDM4EALDH1A1HSD17B10ESR1 | |
| SCHEMBL10381392 | 0.79 | PARP1 (0.50) | PARP1 | |
| SCHEMBL30479656 | 0.79 | PARP1 (0.50) | PARP1 | |
| SCHEMBL6687224 | 0.79 | CRBN (0.34) | PRMT5WDR77PARP1SRC | |
| SCHEMBL10569911 | 0.76 | ADRB2 (0.50) | MAPK1KDM4EALDH1A1HSD17B10ESR1 | |
| SCHEMBL28092163 | 0.76 | SRC (0.61) | MAPK1PARP1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL11167058 | 0.76 | PARP1 (0.39) | PRMT5WDR77PARP1NUDT1SRC | |
| SCHEMBL16973904 | 0.75 | PRMT5 (0.49) | PRMT5WDR77KDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121638-B1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-05-25 | — | — | EP | disclosed |
| CN-102171214-B | Dihydropyridophthalazinone inhibitors of poly (ADP-ribose) polymerase (PARP) | BIOMARIN PHARM INC | 2015-06-24 | — | — | CN | disclosed |
| CN-104478875-A | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARM INC | 2015-04-01 | — | — | CN | disclosed |
| CN-103896942-A | Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) | BIOMARIN PHARM INC | 2014-07-02 | — | — | CN | disclosed |
| CN-102171214-A | Dihydropyridophthalazinone inhibitors of poly (ADP-ribose) polymerase (PARP) | BIOMARIN PHARM INC | 2011-08-31 | — | — | CN | disclosed |
| US-20100286192-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | ANTHONY NEVILLE J | 2010-11-11 | — | — | US | disclosed |
| US-7781454-B2 | Non-nucleoside reverse transcriptase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2010-08-24 | — | — | US | disclosed |
| EP-2121638-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20080275097-A1 | Non-nucleoside reverse transcriptase inhibitors | MERCK SHARP & DOHME LLC | 2008-11-06 | — | — | US | disclosed |
| WO-2008076225-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK & CO., INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| EP-1405848-B1 | TETRAHYDROQUINOLINE DERIVATIVE COMPOUND AND DRUG CONTAINING THE COMPOUND AS ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2008-05-07 | — | — | EP | disclosed |
| EP-1405848-B1 | TETRAHYDROQUINOLINE DERIVATIVE COMPOUND AND DRUG CONTAINING THE COMPOUND AS ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2008-05-07 | — | — | EP | disclosed |
| US-6924295-B2 | Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-08-02 | — | — | US | disclosed |
| US-20040171835-A1 | Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-09-02 | — | — | US | disclosed |
| EP-1405848-A1 | TETRAHYDROQUINOLINE DERIVATIVE COMPOUND AND DRUG CONTAINING THE COMPOUND AS ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275097-A1 | Non-nucleoside reverse transcriptase inhibitors | RNGTT, RRM2B, RRM2 | PRMT5 473/4885WDR77 291/4885MAPK1 2492/4885 |
| US-20100286192-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | RNGTT, RRM2B, RRM2 | PRMT5 473/4885WDR77 291/4885MAPK1 2492/4885 |
| US-20040171835-A1 | Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient | SREBF1, NR1H2, NR1H3 | PRMT5 531/4885WDR77 1552/4885MAPK1 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.