Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807912 | 0.89 | CD274 (0.36) | CD274GABRG2GABRB3GABRA2KMT2A | |
| SCHEMBL27785954 | 0.88 | GABRG2 (0.42) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807969 | 0.88 | HRH4 (0.34) | HRH4GABRG2GABRB3GABRA2KDM4E | |
| SCHEMBL27786008 | 0.85 | CYP11B1 (0.41) | HRH4CRHR1 | |
| SCHEMBL27807911 | 0.84 | HRH4 (0.35) | HRH4KDM4EALDH1A1GAAMAPT | |
| SCHEMBL27785922 | 0.83 | DRD4 (0.37) | GABRG2GABRB3GABRA2KDM4EALDH1A1 | |
| SCHEMBL28787406 | 0.83 | CD38 (0.33) | HRH4GABRG2GABRB3GABRA2KDM4E | |
| SCHEMBL27786138 | 0.83 | GABRG2 (0.42) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27785944 | 0.82 | BCL2L11 (0.33) | GABRG2GABRB3GABRA2KDM4EMAPT | |
| SCHEMBL27807908 | 0.82 | CD274 (0.34) | HRH4CD274GABRG2GABRB3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |