Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807911 | 0.84 | HRH4 (0.35) | CD38HRH4CRHR1KDM4EL3MBTL1 | |
| SCHEMBL27807992 | 0.84 | KDM4E (0.36) | KDM4EGABRG2GABRB3GABRA2MAPT | |
| SCHEMBL27786008 | 0.83 | CYP11B1 (0.41) | HRH4CRHR1TLR7 | |
| SCHEMBL28787429 | 0.83 | HRH4 (0.35) | HRH4CRHR1KDM4EKMT2AGABRG2 | |
| SCHEMBL27807969 | 0.82 | HRH4 (0.34) | HRH4CRHR1KDM4EDHFRKMT2A | |
| SCHEMBL27807928 | 0.82 | USP1 (0.38) | KDM4EMEN1KMT2AL3MBTL1GABRG2 | |
| SCHEMBL27786138 | 0.81 | GABRG2 (0.42) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27785954 | 0.81 | GABRG2 (0.42) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27785944 | 0.81 | BCL2L11 (0.33) | KDM4EGABRG2GABRB3GABRA2MAPT | |
| SCHEMBL2661845 | 0.79 | WDR5 (0.37) | HRH4KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |