Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18135535 | 0.72 | HRH4 (0.46) | ADRB2HRH1KDM4EUSP2SMN1; SMN2 | |
| SCHEMBL18135541 | 0.72 | HRH1 (0.41) | ADRB1ADRB2HRH1KDM4EUSP2 | |
| SCHEMBL16846204 | 0.71 | HRH1 (0.37) | ADRB1HRH1USP2SMN1; SMN2TDP1 | |
| Hydrochloric Acid SCHEMBL16825844 | 0.70 | HRH4 (0.44) | HRH1KDM4EUSP2SMN1; SMN2TDP1 | |
| SCHEMBL3151896 | 0.67 | DPP4 (0.45) | ADRB1ADRB2EPHX2HRH1KDM4E | |
| SCHEMBL3922776 | 0.66 | CHRNB2 (0.54) | ADRB1ADRB2EPHX2HTR2CHTR3A | |
| SCHEMBL2850464 | 0.65 | HRH3 (0.59) | ADRB1ADRB2EPHX2KDM4EUSP2 | |
| SCHEMBL13741399 | 0.64 | ADRB2 (0.48) | ADRB1ADRB2HRH1SMN1; SMN2HTR2C | |
| SCHEMBL15375204 | 0.62 | KDM4E (0.32) | KDM4E | |
| SCHEMBL24963015 | 0.62 | ADRB1 (0.66) | ADRB1ADRB2HRH1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101952286-A | Bicyclic derivatives for use in the treatment of androgen receptor associated conditions | ASTRAZENECA AB | 2011-01-19 | — | — | CN | disclosed |