Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.60 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 5/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL20420823 | 0.96 | NR4A1 (0.56) | NR4A1TTRTHRBNSD2HDAC3 | |
| SCHEMBL2093555 | 0.96 | NR4A1 (0.56) | NR4A1TTRTHRBNSD2HDAC3 | |
| SCHEMBL29354786 | 0.96 | NR4A1 (0.56) | NR4A1TTRTHRBNSD2HDAC3 | |
| SCHEMBL7179151 | 0.96 | NR4A1 (0.56) | NR4A1TTRTHRBNSD2HDAC3 | |
| SCHEMBL30742565 | 0.96 | NR4A1 (0.56) | NR4A1TTRTHRBNSD2HDAC3 | |
| Water SCHEMBL28335545 | 0.94 | NR4A1 (0.54) | NR4A1TTRTHRBNSD2HDAC3 | |
| Water SCHEMBL29985321 | 0.94 | NR4A1 (0.54) | NR4A1TTRTHRBNSD2HDAC3 | |
| Lithium Ion SCHEMBL20420825 | 0.84 | TTR (0.63) | NR4A1TTRNSD2ALDH1A1CYP3A4 | |
| SCHEMBL2951288 | 0.84 | TTR (0.63) | NR4A1TTRNSD2ALDH1A1CYP3A4 | |
| SCHEMBL10383985 | 0.80 | NSD2 (0.44) | NR4A1TTRTHRBNSD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114671785-A | Improved method for synthesizing p-aminonaphthalene sulfonic acid alkali metal salt | 亚什特种化学品有限责任合伙公司 | 2022-06-28 | — | — | CN | disclosed |