Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14293823 | 0.89 | GAA (0.50) | LMNAPOLBSMN1; SMN2PDE4BMEN1 | |
| SCHEMBL12385782 | 0.87 | GAA (0.56) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL23559762 | 0.87 | GAA (0.56) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL10005159 | 0.87 | GAA (0.56) | POLBSMN1; SMN2MAPTGAAALDH1A1 | |
| SCHEMBL12199208 | 0.85 | CHRNB2 (0.42) | LMNAPOLBSMN1; SMN2MEN1MAPT | |
| SCHEMBL15139529 | 0.83 | POLB (0.45) | LMNAPOLBSMN1; SMN2PDE4BMEN1 | |
| SCHEMBL22836888 | 0.82 | ALDH1A1 (0.43) | LMNAPOLBMEN1MAPTKMT2A | |
| SCHEMBL8324436 | 0.81 | POLB (0.61) | LMNAPOLBSMN1; SMN2MEN1MAPT | |
| SCHEMBL10568513 | 0.80 | GAA (0.49) | PDE4BMAPTKMT2AGAAHSD11B1 | |
| SCHEMBL7339506 | 0.79 | LMNA (0.61) | LMNAPOLBSMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015688-A | Muscarinic receptor agonists, compositions, methods of treatment thereof, and processes for preparation thereof | ASTRAZENECA AB | 2011-04-13 | — | — | CN | disclosed |