Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14146761 | 0.89 | BRAF (0.58) | BRAFKDREPHX2MTORPIK3CA | |
| SCHEMBL27862281 | 0.89 | BRAF (0.45) | BRAFKDRTRPV1EPHX2MAPK14 | |
| SCHEMBL27844969 | 0.88 | BRAF (0.45) | BRAFKDRTRPV1EPHX2MAPK14 | |
| SCHEMBL27862533 | 0.88 | FAAH (0.46) | BRAFKDRTRPV1CDK1IGF1R | |
| SCHEMBL27844968 | 0.87 | SRC (0.45) | BRAFKDRMAPK14CCNCCDK8 | |
| SCHEMBL27845059 | 0.87 | BRAF (0.44) | BRAFKDRTRPV1EPHX2CA9 | |
| SCHEMBL27844960 | 0.86 | CCR2 (0.46) | BRAFKDRTRPV1EPHX2CA9 | |
| SCHEMBL28793758 | 0.85 | BRAF (0.45) | BRAFKDRTRPV1CA9MAPK14 | |
| SCHEMBL27845065 | 0.85 | BRAF (0.45) | BRAFKDRTRPV1EPHX2CA9 | |
| SCHEMBL27844948 | 0.84 | BRAF (0.44) | BRAFKDRTRPV1CA9MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102250065-A | Substituted triazine phenyl urea derivatives and application thereof | ZHEJIANG HISUN PHARM CO LTD | 2011-11-23 | — | — | CN | disclosed |