Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28796303 | 0.85 | TSHR (0.40) | ALDH1A1LMNAPOLBATRMEN1 | |
| SCHEMBL23092188 | 0.83 | POLB (0.39) | ALDH1A1LMNAPOLBATRMAPT | |
| SCHEMBL29793541 | 0.81 | EGFR (0.38) | ALDH1A1LMNAPOLBATRMAPT | |
| SCHEMBL23092191 | 0.81 | EGFR (0.38) | ALDH1A1LMNAPOLBATRMAPT | |
| SCHEMBL15528303 | 0.74 | ALDH1A1 (0.42) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL26695909 | 0.74 | ALDH1A1 (0.42) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL165273 | 0.72 | RXRA (0.40) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL18418889 | 0.72 | ALDH1A1 (0.39) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL15528332 | 0.71 | CYP2C9 (0.39) | ALDH1A1LMNAPOLBKMT2ACYP4F2 | |
| SCHEMBL29258348 | 0.70 | L3MBTL1 (0.37) | ALDH1A1LMNAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119775277-A | Compounds as modulators of LRRK2, NUAK1 and/or TYK2 kinases for the treatment of, for example, autoimmune diseases | 原真股份有限公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-114793435-B | Compounds as modulators of LRRK2, NUAK1 and/or TYK2 kinases for the treatment of, for example, autoimmune diseases | 原真股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-115103844-A | 1, 4-dihydrobenzo [ D ] pyrazolo [3,4-F ] [1,3] diazepine derivatives and related compounds as modulators of LRRK2, NUAK1 and/or TYK2 kinases for the treatment of e.g. autoimmune diseases | 原真股份有限公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-114793435-A | 1, 4-dihydrobenzo [ D ] pyrazolo [3,4-F ] [1,3] diazepine derivatives and related compounds as modulators of LRRK2, NUAK1, and/or TYK2 kinases for the treatment of, for example, autoimmune diseases | 原真股份有限公司 | 2022-07-26 | — | — | CN | disclosed |