Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23092191 | 1.00 | EGFR (0.38) | EGFRTDP1ALDH1A1POLBLMNA | |
| SCHEMBL23092237 | 0.87 | ALDH1A1 (0.40) | EGFRALDH1A1POLBLMNAATR | |
| SCHEMBL23092188 | 0.86 | POLB (0.39) | EGFRTDP1ALDH1A1POLBLMNA | |
| SCHEMBL28796322 | 0.81 | ALDH1A1 (0.40) | ALDH1A1POLBLMNAATRMAPT | |
| SCHEMBL28796303 | 0.75 | TSHR (0.40) | EGFRALDH1A1POLBLMNAATR | |
| SCHEMBL26695909 | 0.72 | ALDH1A1 (0.42) | EGFRALDH1A1POLBLMNAMAPT | |
| SCHEMBL30926242 | 0.71 | OPRK1 (0.41) | EGFRTDP1ALDH1A1POLBLMNA | |
| SCHEMBL15528303 | 0.69 | ALDH1A1 (0.42) | EGFRALDH1A1POLBLMNAMAPT | |
| SCHEMBL165273 | 0.69 | RXRA (0.40) | TDP1ALDH1A1POLBLMNAMAPT | |
| SCHEMBL31121566 | 0.69 | MAPT (0.38) | EGFRALDH1A1POLBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119775277-A | Compounds as modulators of LRRK2, NUAK1 and/or TYK2 kinases for the treatment of, for example, autoimmune diseases | 原真股份有限公司 | 2025-04-08 | — | — | CN | disclosed |
| CN-114793435-B | Compounds as modulators of LRRK2, NUAK1 and/or TYK2 kinases for the treatment of, for example, autoimmune diseases | 原真股份有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-115103844-A | 1, 4-dihydrobenzo [ D ] pyrazolo [3,4-F ] [1,3] diazepine derivatives and related compounds as modulators of LRRK2, NUAK1 and/or TYK2 kinases for the treatment of e.g. autoimmune diseases | 原真股份有限公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-114793435-A | 1, 4-dihydrobenzo [ D ] pyrazolo [3,4-F ] [1,3] diazepine derivatives and related compounds as modulators of LRRK2, NUAK1, and/or TYK2 kinases for the treatment of, for example, autoimmune diseases | 原真股份有限公司 | 2022-07-26 | — | — | CN | disclosed |