Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | G6PD | P11413 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556554 | 0.86 | KMT2A (0.75) | LMNAKMT2AMAPTMEN1NPC1 | |
| SCHEMBL27877118 | 0.85 | SMN1; SMN2 (0.51) | LMNAKMT2AMAPTMEN1NPC1 | |
| SCHEMBL2664519 | 0.82 | SMN1; SMN2 (0.67) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL8556694 | 0.81 | KMT2A (0.69) | LMNAKMT2AMAPTMEN1NPC1 | |
| SCHEMBL18762149 | 0.79 | KMT2A (0.73) | LMNAKMT2AMAPTMEN1NPC1 | |
| SCHEMBL27860322 | 0.78 | TP53 (0.55) | LMNAKMT2AMAPTMEN1NPC1 | |
| SCHEMBL8554413 | 0.78 | LMNA (0.65) | LMNAKMT2AMAPTMEN1NPC1 | |
| SCHEMBL17318577 | 0.76 | KDM4E (0.73) | KMT2AMAPTMEN1NPC1RAB9A | |
| SCHEMBL8554147 | 0.76 | LMNA (0.65) | LMNAKMT2AMAPTMEN1NPC1 | |
| SCHEMBL8559786 | 0.76 | RAB9A (0.74) | LMNAKMT2AMAPTMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102532126-B | 2-substituted-4-chloro-5-[5-subtsituted amino-2-(1,3,4-thiadiazole)-sulfydryl]-3(2H)- pyridazinone derivatives, and preparation method and application thereof | UNIV GUIZHOU | 2014-06-18 | — | — | CN | disclosed |
| CN-102532126-A | 2-substituted-4-chloro-5-[5-subtsituted amino-2-(1,3,4-thiadiazole)-sulfydryl]-3(2H)- pyridazinone derivatives, and preparation method and application thereof | UNIV GUIZHOU | 2012-07-04 | — | — | CN | disclosed |