Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 4/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 5/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27867731 | 0.85 | CCR2 (0.43) | ACLYCCR2PHGDHMRGPRX4PPARG | |
| SCHEMBL12096936 | 0.83 | ACLY (0.52) | ACLYCCR2PHGDHCA1CA2 | |
| SCHEMBL27884477 | 0.80 | PHGDH (0.44) | ACLYCCR2PHGDHCSNK2A2CSNK2B | |
| SCHEMBL28797215 | 0.80 | DHCR7 (0.41) | ACLYPHGDHCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL28800057 | 0.80 | ACLY (0.43) | ACLYCCR2PHGDHCA1CA2 | |
| SCHEMBL27713455 | 0.78 | PPARG (0.54) | ACLYNPC1RAB9ASMN1; SMN2PPARG | |
| SCHEMBL27884471 | 0.77 | ACLY (0.37) | ACLYCCR2PHGDHPPARGPPARD | |
| SCHEMBL27733850 | 0.76 | PPARG (0.56) | PPARGPPARDPPARA | |
| SCHEMBL28946031 | 0.74 | ACLY (0.35) | ACLYPHGDHSMN1; SMN2PPARGPPARD | |
| SCHEMBL27884203 | 0.74 | PPARG (0.34) | ACLYCCR2PHGDHPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |