Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 6/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12096936 | 0.85 | ACLY (0.52) | ACLYCCR2PHGDHCA1CA2 | |
| SCHEMBL27867732 | 0.83 | CCR2 (0.45) | ACLYCCR2PHGDHMRGPRX4PPARG | |
| SCHEMBL27713457 | 0.83 | PSEN1 (0.46) | ACLYPHGDHPSEN1PSEN2APH1B | |
| SCHEMBL28775103 | 0.81 | MEN1 (0.41) | ACLYPHGDHPSEN1PSEN2APH1B | |
| SCHEMBL28800056 | 0.80 | ACLY (0.41) | ACLYCCR2PHGDHCA1CA2 | |
| SCHEMBL27733784 | 0.80 | PSEN1 (0.42) | ACLYPHGDHPSEN1PSEN2APH1B | |
| SCHEMBL27733852 | 0.79 | PSEN1 (0.39) | ACLYPHGDHPSEN1PSEN2APH1B | |
| SCHEMBL27833766 | 0.78 | PHGDH (0.38) | ACLYPHGDHPSEN1PSEN2APH1B | |
| SCHEMBL28797216 | 0.78 | PHGDH (0.41) | ACLYPHGDHPSEN1PSEN2APH1B | |
| SCHEMBL28770821 | 0.77 | PTGS2 (0.39) | ACLYPHGDHPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596906-A | Use of indole derivatives as NURR-1 activators as agents for the treatment of Parkinson's disease | FOURNIER LAB SA | 2012-07-18 | — | — | CN | disclosed |