Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 9/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.41 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2882294 | 0.83 | FYN (0.48) | SMN1; SMN2ALDH1A1KDM4ECSNK2A1FYN | |
| SCHEMBL2212033 | 0.83 | FYN (0.44) | SMN1; SMN2ALDH1A1KDM4EFYNMEN1 | |
| SCHEMBL2882015 | 0.81 | CYP17A1 (0.47) | SMN1; SMN2ALDH1A1KDM4EFYNNPC1 | |
| SCHEMBL2881754 | 0.79 | MAPT (0.39) | SMN1; SMN2ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL2884265 | 0.76 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1KDM4ECSNK2A1NPC1 | |
| SCHEMBL2880093 | 0.76 | RAD52 (0.48) | SMN1; SMN2ALDH1A1KDM4EFYNNPC1 | |
| SCHEMBL2212453 | 0.75 | POLB (0.45) | ALDH1A1KDM4ECSNK2A1FYNRAB9A | |
| SCHEMBL2319146 | 0.70 | FYN (0.51) | SMN1; SMN2ALDH1A1KDM4EFYNNPC1 | |
| SCHEMBL969807 | 0.69 | RAB9A (0.65) | SMN1; SMN2ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL6670281 | 0.68 | HTR2A (0.71) | SMN1; SMN2ALDH1A1KDM4EFYNNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745446-B2 | Pyrazolo[1,5-c]pyrimidines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-29 | — | — | US | disclosed |
| US-20070254046-A1 | Novel Pyrazolopyrimidines | ALTANA PHARMA AG (DE) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254046-A1 | Novel Pyrazolopyrimidines | MCL1, RARS2, CDK4 | SMN1; SMN2 1421/4885ALDH1A1 1334/4885KDM4E 3784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.