Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.59 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.59 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.58 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.54 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8577619 | 0.88 | SMN1; SMN2 (0.70) | RAB9ACYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL3786463 | 0.86 | NQO2 (0.73) | RAB9ACYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL12999591 | 0.85 | NPC1 (0.69) | RAB9ACYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL9293265 | 0.83 | IDO1 (0.64) | RAB9ACYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL4654909 | 0.83 | ALDH1A1 (0.67) | RAB9ACYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL14384612 | 0.83 | CNR1 (0.71) | CYP17A1CYP11B1CYP11B2HSD17B1HSD17B2 | |
| SCHEMBL9339755 | 0.82 | SMN1; SMN2 (0.79) | RAB9AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1749196 | 0.82 | MEN1 (0.59) | RAB9ACYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL12919978 | 0.81 | CYP17A1 (0.60) | RAB9ACYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL6792137 | 0.81 | CYP17A1 (0.60) | RAB9ACYP17A1CYP11B1CYP11B2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915557-A1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2021-12-01 | — | — | EP | disclosed |
| US-11147801-B2 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2021-10-19 | — | — | US | disclosed |
| EP-3615027-B1 | METHODS OF USE FOR TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECH LTD (IN) | 2021-07-14 | — | — | EP | disclosed |
| US-20190105304-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2019-04-11 | — | — | US | disclosed |
| US-9937155-B2 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-04-10 | — | — | US | disclosed |
| US-9937155-B2 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2018-04-10 | — | — | US | disclosed |
| US-20180021311-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2018-01-25 | — | — | US | disclosed |
| US-20180021311-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2018-01-25 | — | — | US | disclosed |
| US-20170224663-A1 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-08-10 | — | — | US | disclosed |
| US-20170224663-A1 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2017-08-10 | — | — | US | disclosed |
| US-9630932-B2 | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2017-04-25 | — | — | US | disclosed |
| US-9630932-B2 | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2017-04-25 | — | — | US | disclosed |
| US-20160200693-A1 | Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2016-07-14 | — | — | US | disclosed |
| US-20160200693-A1 | Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2016-07-14 | — | — | US | disclosed |
| US-7871982-B2 | Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient | MEIJI SEIKA KAISHA, LTD. (JP) | 2011-01-18 | — | — | US | disclosed |
| US-20090156512-A1 | potent activity against resistant pneumococci | MEIJI SEIKA KAISHA, LTD. (JP) | 2009-06-18 | — | — | US | disclosed |
| EP-1970377-A1 | LINCOMYCIN DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT | MEIJI SEIKA KAISHA LTD. (JP) | 2008-09-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180021311-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | DHODH, DHFR, DPYD | RAB9A 4643/4885CYP17A1 258/4885CYP11B1 121/4885 |
| US-20190105304-A1 | TRISUBSTITUTED BENZOTRIAZOLE DERIVATIVES AS DIHYDROOROTATE OXYGENASE INHIBITORS | DHODH, DHFR, DPYD | RAB9A 4643/4885CYP17A1 258/4885CYP11B1 121/4885 |
| US-20160200693-A1 | Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | DHODH, HAAO, TALDO1 | RAB9A 4469/4885CYP17A1 240/4885CYP11B1 152/4885 |
| US-11147801-B2 | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors | DHODH, DHFR, DDO | RAB9A 4744/4885CYP17A1 213/4885CYP11B1 114/4885 |
| US-20090156512-A1 | potent activity against resistant pneumococci | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NAT1, NPM1 | RAB9A 377/4885CYP17A1 3352/4885CYP11B1 886/4885 |
| US-20170224663-A1 | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors | DHODH, DHFR, DDO | RAB9A 4744/4885CYP17A1 213/4885CYP11B1 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.