Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167693 | 0.80 | DYRK1A (0.35) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27683380 | 0.79 | DYRK1A (0.34) | MAPTALDH1A1GAAMAPK1RECQL | |
| SCHEMBL9978669 | 0.77 | SMN1; SMN2 (0.33) | MEN1KMT2ALMNARAB9ASMN1; SMN2 | |
| SCHEMBL2427435 | 0.74 | — | — | |
| Ethane SCHEMBL28967597 | 0.72 | HPGD (0.39) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL627520 | 0.72 | MAPK1 (0.57) | MAPTLMNAGAARAB9AHTT | |
| SCHEMBL162091 | 0.71 | HPGD (0.41) | MAPTCYP3A4ALOX15LMNABLM | |
| SCHEMBL8023464 | 0.69 | — | — | |
| SCHEMBL3582886 | 0.69 | — | — | |
| SCHEMBL10399828 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104203937-A | 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity | HOFFMANN LA ROCHE | 2014-12-10 | — | — | CN | disclosed |
| CN-104125959-A | Heteroaryl pyridone and aza-pyridone compounds as inhibitors of BTK activity | HOFFMANN LA ROCHE | 2014-10-29 | — | — | CN | disclosed |
| CN-104105697-A | Bicyclic piperazine compounds | HOFFMANN LA ROCHE | 2014-10-15 | — | — | CN | disclosed |
| CN-103201277-A | Pyridazinones, method of making, and method of use thereof | GILEAD CONNECTICUT INC | 2013-07-10 | — | — | CN | disclosed |
| CN-103189369-A | Pyridone/pyrazinones, methods of making, and methods of use thereof | GILEAD CONNECTICUT INC | 2013-07-03 | — | — | CN | disclosed |
| CN-103168039-A | Imidazopyridine type SYK inhibitors | GILEAD SCIENCES INC | 2013-06-19 | — | — | CN | disclosed |
| CN-103038233-A | Pyridone and azapyridone compounds and methods of use | GILEAD CONNECTICUT INC | 2013-04-10 | — | — | CN | disclosed |