Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 9/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27488566 | 0.77 | RIPK1 (0.51) | RIPK1HRH3GRIN2B | |
| SCHEMBL28685326 | 0.77 | ALDH1A1 (0.49) | RIPK1 | |
| SCHEMBL2026837 | 0.76 | RORC (0.51) | HTRA1MEN1KMT2A | |
| SCHEMBL31410105 | 0.76 | RORC (0.51) | HTRA1MEN1KMT2A | |
| SCHEMBL27979570 | 0.76 | SLC18A3 (0.33) | RIPK1 | |
| SCHEMBL27713286 | 0.76 | ATM (0.33) | — | |
| SCHEMBL27668157 | 0.74 | RIPK1 (0.45) | RIPK1HRH3 | |
| SCHEMBL27822443 | 0.74 | SLC6A2 (0.46) | RIPK1HRH3 | |
| SCHEMBL27801641 | 0.74 | SLC6A2 (0.46) | RIPK1HRH3 | |
| SCHEMBL28017484 | 0.73 | MEN1 (0.43) | RIPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102884062-B | Aminopyrimidine inhibitors of kinases | 嘉世高制药公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-102884062-A | Aminopyrimidine kinase inhibitors | JASCO PHARMACEUTICALS LLC | 2013-01-16 | — | — | CN | disclosed |