Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CPB1 | P15086 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3604589 | 0.87 | KMT2A (0.54) | MEN1KMT2ASLC18A3KCNH2ALDH1A1 | |
| SCHEMBL27689722 | 0.86 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL27751800 | 0.86 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL27770244 | 0.85 | MGLL (0.40) | MEN1KMT2AELANESLC18A3MAPK1 | |
| SCHEMBL27597017 | 0.85 | ELANE (0.46) | MEN1KMT2AELANEMGLL | |
| SCHEMBL2882463 | 0.76 | KDM4E (0.51) | MEN1KMT2A | |
| SCHEMBL28265092 | 0.75 | ALDH1A1 (0.38) | ELANEALDH1A1MAPK1RIPK1 | |
| SCHEMBL27488566 | 0.74 | RIPK1 (0.51) | SLC18A3KCNH2ALDH1A1RIPK1 | |
| SCHEMBL28803045 | 0.73 | RIPK1 (0.39) | MEN1KMT2ARIPK1 | |
| SCHEMBL27890346 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104781238-A | Pyrazole carboxamide compounds, compositions and methods of use | HOFFMANN LA ROCHE | 2015-07-15 | — | — | CN | disclosed |