Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 20/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 19/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 19/20 | 0.41 |
| ▸ | CASP1 | P29466 | 17/20 | 0.41 |
| ▸ | CASP7 | P55210 | 16/20 | 0.41 |
| ▸ | HPGD | P15428 | 13/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 11/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GLA | P06280 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1847339 | 0.91 | ALDH1A1 (0.48) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 | |
| Fumaric Acid SCHEMBL194797 | 0.88 | POLB (0.42) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 | |
| Maleic Acid SCHEMBL2882692 | 0.88 | POLB (0.42) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 | |
| Phosphoric Acid SCHEMBL8808804 | 0.87 | ALDH1A1 (0.44) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 | |
| Fumaric Acid SCHEMBL8809775 | 0.84 | CYP1A2 (0.48) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 | |
| Maleic Acid SCHEMBL8809763 | 0.84 | CYP1A2 (0.48) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 | |
| Maleic Acid SCHEMBL8579856 | 0.83 | MAPK8 (0.35) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 | |
| SCHEMBL1845477 | 0.79 | ALDH1A1 (0.49) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 | |
| Maleic Acid SCHEMBL8810283 | 0.78 | HSD17B10 (0.40) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 | |
| Fumaric Acid SCHEMBL8810291 | 0.78 | HSD17B10 (0.40) | HSD17B10ALDH1A1CYP1A2CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010087527-A1 | ULTRAVIOLET ABSORBERS, AND PHARMACEUTICAL COMPOSITIONS AND COSMETICS CONTAINING PYRIMIDINE COMPOUNDS FOR UV PROTECTION | AWAYA AKIRA (JP) | 2010-08-05 | — | — | WO | disclosed |