Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 19/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 18/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 18/20 | 0.48 |
| ▸ | CASP1 | P29466 | 14/20 | 0.48 |
| ▸ | CASP7 | P55210 | 13/20 | 0.48 |
| ▸ | HPGD | P15428 | 11/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.45 |
| ▸ | USP2 | O75604 | 9/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.44 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8809775 | 1.00 | CYP1A2 (0.48) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL8810107 | 0.92 | CYP1A2 (0.55) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| Maleic Acid SCHEMBL2880482 | 0.84 | HSD17B10 (0.41) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL9686746 | 0.78 | ALDH1A1 (0.43) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL8812154 | 0.76 | ALDH1A1 (0.49) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| SCHEMBL1847339 | 0.74 | ALDH1A1 (0.48) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| Phosphoric Acid SCHEMBL8808804 | 0.74 | ALDH1A1 (0.44) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| Maleic Acid SCHEMBL2882692 | 0.73 | POLB (0.42) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| Fumaric Acid SCHEMBL194797 | 0.73 | POLB (0.42) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 | |
| Maleic Acid SCHEMBL8579856 | 0.70 | MAPK8 (0.35) | CYP1A2ALDH1A1HSD17B10CASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0257102-B1 | AGENTS FOR TREATING NEUROPHATHY | MITSUI PETROCHEMICAL IND (JP) | 1997-11-19 | — | — | EP | disclosed |
| EP-0799617-A2 | Therapeutic agent for neurological diseases | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-08 | — | — | EP | disclosed |
| US-4959368-A | PYRIMIDINE DERIVATIVES | MITSUI PETROCHEMICAL INDUSTRIES LTD. (JP) | 1990-09-25 | — | — | US | disclosed |