Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL71629 | 0.85 | MAPT (0.47) | KDM4EMAPTLMNAMEN1KMT2A | |
| SCHEMBL988776 | 0.73 | FABP1 (0.58) | KDM4ELMNAMEN1KMT2AHPGD | |
| SCHEMBL284700 | 0.73 | CALM1 (0.63) | CALM1ADRA2AADRA2BADRA2CMAPT | |
| SCHEMBL10617361 | 0.72 | CYP11B1 (0.45) | CALM1IDH1 | |
| SCHEMBL19187359 | 0.71 | ALDH1A1 (0.65) | CALM1MAPTLMNAMEN1KMT2A | |
| SCHEMBL25557237 | 0.71 | ALDH1A1 (0.65) | CALM1MAPTLMNAMEN1KMT2A | |
| SCHEMBL4775214 | 0.71 | NPC1 (0.53) | ADRA2AKDM4EMAPTLMNAMEN1 | |
| SCHEMBL4774579 | 0.71 | HTR7 (0.46) | KDM4EMAPTLMNAMEN1KMT2A | |
| SCHEMBL1711863 | 0.71 | CALM1 (0.42) | CALM1KDM4EMAPTLMNASMN1; SMN2 | |
| SCHEMBL13308523 | 0.69 | ALDH1A1 (0.68) | CALM1MAPTLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103201267-A | AMPK-activating heterocyclic compounds and methods of use thereof | RIGEL PHARMACEUTICALS INC | 2013-07-10 | — | — | CN | claimed |