Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1908393 | 0.85 | HTT (0.44) | HTTCA1CA2SMN1; SMN2LMNA | |
| SCHEMBL1533960 | 0.85 | HTT (0.45) | HTTCA1CA2SMN1; SMN2LMNA | |
| SCHEMBL7628088 | 0.83 | CA1 (0.45) | HTTCA1CA2LMNACYP2D6 | |
| SCHEMBL666878 | 0.81 | CA1 (0.51) | CA1CA2LMNAACHEKMT2A | |
| SCHEMBL10858091 | 0.80 | HTT (0.48) | HTTCA1CA2LMNACYP2D6 | |
| SCHEMBL3005218 | 0.80 | HTT (0.53) | HTTCA1CA2SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL15318972 | 0.79 | CA1 (0.50) | CA1CA2LMNAACHEKMT2A | |
| SCHEMBL28436770 | 0.79 | HTT (0.46) | HTTCA1CA2SMN1; SMN2LMNA | |
| SCHEMBL2913208 | 0.78 | HTT (0.45) | HTTCA1CA2SMN1; SMN2LMNA | |
| SCHEMBL28808931 | 0.76 | HTT (0.40) | HTTCA1CA2CYP2D6ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109207110-B | Hybrid cross-linked dynamic polymer | 厦门天策材料科技有限公司 | 2022-08-12 | — | — | CN | disclosed |
| CN-109206580-B | Hybrid cross-linked dynamic polymer | 厦门天策材料科技有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-109207110-A | A kind of hybrid cross-linked dynamic aggregation object | 翁秋梅 | 2019-01-15 | — | — | CN | disclosed |
| CN-109206578-A | A kind of energy-absorbing method based on hybrid cross-linked dynamic aggregation object | 翁秋梅 | 2019-01-15 | — | — | CN | disclosed |