Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | EEF2K | O00418 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | EEF2 | P13639 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ITK | Q08881 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL666878 | 0.98 | CA1 (0.51) | CA1CA2ACHEHDAC8ALDH1A1 | |
| SCHEMBL28404964 | 0.91 | CA1 (0.46) | CA1CA2ACHEHDAC8 | |
| SCHEMBL17422678 | 0.91 | CA1 (0.46) | CA1CA2ACHEHDAC8LMNA | |
| SCHEMBL22372285 | 0.86 | CA1 (0.45) | CA1CA2ACHEHDAC8MEN1 | |
| SCHEMBL666911 | 0.85 | CA1 (0.42) | CA1CA2ACHEHDAC8 | |
| SCHEMBL14988896 | 0.85 | CA1 (0.44) | CA1CA2ACHEHDAC8ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1884666 | 0.82 | ACHE (0.47) | CA1CA2ACHEHDAC8ALDH1A1 | |
| SCHEMBL319282 | 0.79 | ACHE (0.45) | CA1CA2ACHEHDAC8ALDH1A1 | |
| SCHEMBL28808933 | 0.79 | HTT (0.47) | CA1CA2ACHELMNAMEN1 | |
| Hydrochloric Acid SCHEMBL295048 | 0.78 | KMT2A (0.47) | CA1CA2ACHEHDAC8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834251-B1 | IONIC COMPOUNDS HAVING A SILYLOXY GROUP | HYDRO QUEBEC (CA) | 2019-11-13 | — | — | EP | disclosed |
| US-9969757-B2 | Ionic compounds having a silyloxy group | HYDRO-QUEBEC (CA) | 2018-05-15 | — | — | US | disclosed |
| US-20150093655-A1 | IONIC COMPOUNDS HAVING A SILYLOXY GROUP | HYDRO-QUEBEC (CA) | 2015-04-02 | — | — | US | disclosed |
| EP-2834251-A1 | IONIC COMPOUNDS HAVING A SILYLOXY GROUP | Hydro-Québec (CA) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013149349-A1 | IONIC COMPOUNDS HAVING A SILYLOXY GROUP | HYDRO-QUéBEC (CA) | 2013-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150093655-A1 | IONIC COMPOUNDS HAVING A SILYLOXY GROUP | EPCAM, ILK, VIM | ACHE 589/4885CA1 99/4885CA2 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.