SCHEMBL28809698

SCHEMBL28809698

Fc1ccc(C(F)(F)Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 3/20 0.41
CYP19A1 P11511 4/20 0.41
RAB9A P51151 2/20 0.39
USP2 O75604 1/20 0.39
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
ACHE P22303 1/20 0.36
HSD11B1 P28845 1/20 0.35
PAX8 Q06710 1/20 0.35
NR1I2 O75469 1/20 0.34
RORC P51449 1/20 0.34
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
CYP1A1 P04798 1/20 0.33
CYP1B1 Q16678 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4204801 0.87 PDE2A (0.36) CYP19A1MAPK1ORAI1ORAI2ORAI3
Hydrochloric Acid SCHEMBL8577339 0.84 PDE2A (0.35) CYP19A1MAPK1IDO1ORAI1ORAI2
Hydrochloric Acid SCHEMBL8577343 0.84 PDE2A (0.35) CYP19A1MAPK1IDO1ORAI1ORAI2
SCHEMBL11240836 0.79 PDE2A (0.32) MAPK1
SCHEMBL11599184 0.79 TSHR (0.50) MAPK1
SCHEMBL1508480 0.79 ALDH1A1 (0.50) ORAI1ORAI2ORAI3TRPV6
SCHEMBL1507995 0.79 RAB9A (0.46) KCNN4CYP19A1RAB9AUSP2CA1
SCHEMBL3158793 0.79 TSHR (0.50) KCNN4CYP19A1RAB9AUSP2CA1
SCHEMBL5394608 0.79 KCNN4 (0.42) KCNN4CYP19A1RAB9AUSP2CA1
SCHEMBL4460787 0.79 KCNN4 (0.42) KCNN4CYP19A1RAB9AUSP2CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102134175-B Preparation method of benzyl fluorine organic compound JIANGSU WEIER CHEMICAL CO LTD 2014-03-26 CN disclosed