Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 4/20 | 0.34 |
| ▸ | HTR1D | P28221 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877321 | 0.84 | HTR1A (0.46) | LMNAHTR1AADRA2BHTR2AHTR2B | |
| SCHEMBL2788456 | 0.79 | LMNA (0.48) | LMNAHTR1AADRA2BHTR2AHTR2B | |
| SCHEMBL2788593 | 0.77 | LMNA (0.51) | LMNAHTR1AADRA2BHTR2AHTR2B | |
| SCHEMBL2880030 | 0.75 | LMNA (0.47) | LMNAHTR1AADRA2BHTR2AHTR2B | |
| SCHEMBL189975 | 0.74 | HTR1A (0.58) | LMNAHTR1AADRA2BHTR2AHTR2B | |
| SCHEMBL2789287 | 0.72 | HTR1A (0.58) | LMNAHTR1AADRA2BHTR2AHTR2B | |
| SCHEMBL13081208 | 0.70 | LMNA (0.64) | LMNAHTR1AADRA2BHTR2AHTR2B | |
| SCHEMBL13081207 | 0.69 | LMNA (0.66) | LMNAHTR1AADRA2BHTR2AHTR2B | |
| SCHEMBL189974 | 0.69 | HTR1A (0.68) | LMNAHTR1AADRA2BHTR2AHTR2B | |
| Oxalic Acid SCHEMBL2788592 | 0.68 | HTR1A (0.67) | LMNAHTR1AADRA2BHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010113183-A2 | PROCESS FOR THE PREPARATION OF 1-[[[3-[2-(DIMETHYLAMINO)ETHYL]-1H-INDOL-5-YL]METHYL]SULFONYL] PYRROLIDINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | MSN LABORATORIES LIMITED (IN) | 2010-10-07 | — | — | WO | disclosed |