Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR27 | Q9NS67 | 4/20 | 0.54 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.54 |
| ▸ | KIF11 | P52732 | 2/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | ABL2 | P42684 | 1/20 | 0.48 |
| ▸ | BLK | P51451 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679036 | 0.81 | PTGS1 (0.52) | GPR27AVPR2TRPV1AURKACHEK2 | |
| SCHEMBL23002357 | 0.79 | GPR27 (0.48) | GPR27AVPR2NR3C2KDM4ELMNA | |
| SCHEMBL12334377 | 0.78 | RORC (0.58) | GPR27AVPR2TRPV1AURKACHEK2 | |
| SCHEMBL31240769 | 0.76 | KIF11 (0.51) | GPR27AVPR2KIF11MEN1KMT2A | |
| SCHEMBL1160927 | 0.75 | HDAC1 (0.52) | TRPV1AURKACHEK2CSF1RRET | |
| SCHEMBL1417617 | 0.74 | KMT2A (0.49) | AURKACHEK2CSF1RRETFLT4 | |
| SCHEMBL7319545 | 0.73 | ORAI1 (0.66) | AURKACHEK2CSF1RRETFLT4 | |
| SCHEMBL13485802 | 0.73 | LMNA (0.61) | AURKACHEK2CSF1RRETFLT4 | |
| SCHEMBL27801156 | 0.72 | AURKA (0.49) | GPR27AVPR2NR3C2AURKACHEK2 | |
| SCHEMBL30133947 | 0.72 | KMT2A (0.49) | KIF11AURKACHEK2CSF1RRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102573994-B | Novel bicyclic urea compounds | MERCK PATENT GMBH | 2015-06-24 | — | — | CN | disclosed |