Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CNR1 | P21554 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | PKM | P14618 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | YAP1 | P46937 | 1/20 | 0.59 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | PKLR | P30613 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15100910 | 0.85 | LMNA (0.74) | LMNACNR1GAAPKMSMN1; SMN2 | |
| SCHEMBL28819238 | 0.85 | CNR1 (0.62) | LMNACNR1GAAPKMRAB9A | |
| SCHEMBL18711333 | 0.84 | LMNA (0.69) | LMNACNR1GAAPKMMEN1 | |
| SCHEMBL4265072 | 0.83 | CACNA2D1 (0.65) | LMNACNR1GAAPKMKMT2A | |
| SCHEMBL18701978 | 0.81 | LMNA (0.66) | LMNACNR1GAAPKMSMN1; SMN2 | |
| SCHEMBL1498586 | 0.81 | CNR1 (0.47) | LMNACNR1GAAMEN1KMT2A | |
| SCHEMBL20300422 | 0.80 | PKM (0.71) | LMNAGAAPKMRAB9AMEN1 | |
| SCHEMBL1498527 | 0.80 | CACNA1B (0.47) | CNR1GAAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2312877 | 0.79 | LMNA (0.62) | LMNACNR1GAAPKMSMN1; SMN2 | |
| SCHEMBL1945062 | 0.79 | L3MBTL1 (0.80) | LMNACNR1GAAPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114634465-B | Pentadienone derivative containing sulfonyl piperazine as well as preparation method and application thereof | 贵州大学 | 2023-05-30 | — | — | CN | disclosed |
| CN-114634465-A | Sulfonyl piperazine-containing pentadiene ketone derivative and preparation method and application thereof | 贵州大学 | 2022-06-17 | — | — | CN | disclosed |