Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | BAX | Q07812 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL356479 | 0.91 | LTA4H (0.67) | LTA4HTSHRSRCCYP2C9CYP2C19 | |
| Diphenylether SCHEMBL17801642 | 0.91 | LTA4H (0.67) | LTA4HTSHRSRCCYP2C9CYP2C19 | |
| Diphenylether SCHEMBL28278866 | 0.88 | LTA4H (0.63) | LTA4HTSHRSRCCYP2C9CYP2C19 | |
| Diphenylether SCHEMBL27662442 | 0.88 | LTA4H (0.63) | LTA4HTSHRSRCCYP2C9CYP2C19 | |
| Diphenylether SCHEMBL27797017 | 0.88 | LTA4H (0.63) | LTA4HTSHRSRCCYP2C9CYP2C19 | |
| Diphenylether SCHEMBL8837235 | 0.88 | LTA4H (0.71) | LTA4HTSHRNR1H2BAXCA1 | |
| Diphenylether SCHEMBL51188 | 0.88 | LTA4H (0.71) | LTA4HTSHRNR1H2BAXCA1 | |
| Diphenylether SCHEMBL28328603 | 0.86 | TSHR (0.50) | LTA4HTSHRSRCCYP2C9CYP2C19 | |
| Diphenylether SCHEMBL4624646 | 0.83 | LTA4H (0.63) | LTA4HTSHRNR1H2BAXCA1 | |
| Diphenylether SCHEMBL4623898 | 0.83 | LTA4H (0.63) | LTA4HTSHRNR1H2BAXCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105080421-B | A kind of preparation method of ethylene glycol phenyl ether phosphate monoester surfactant | 马鞍山市鸿翮实业有限公司 | 2017-09-26 | — | — | CN | claimed |
| CN-105080421-A | Preparation method of ethylene glycol monophenyl ether phosphomonoester surfactant | MAANSHAN CITY HONGHE IND CO LTD | 2015-11-25 | — | — | CN | claimed |
| CN-108602670-A | Water-Based Nanoparticle Dispersions | 纳米技术工业解决方案公司 | 2018-09-28 | — | — | CN | disclosed |
| CN-105080421-B | A kind of preparation method of ethylene glycol phenyl ether phosphate monoester surfactant | 马鞍山市鸿翮实业有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-105080421-B | A kind of preparation method of ethylene glycol phenyl ether phosphate monoester surfactant | 马鞍山市鸿翮实业有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-105080421-B | A kind of preparation method of ethylene glycol phenyl ether phosphate monoester surfactant | 马鞍山市鸿翮实业有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-105080421-A | Preparation method of ethylene glycol monophenyl ether phosphomonoester surfactant | MAANSHAN CITY HONGHE IND CO LTD | 2015-11-25 | — | — | CN | disclosed |