Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Diphenylether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.56 |
| ▸ | BAX | Q07812 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diphenylether SCHEMBL356479 | 1.00 | LTA4H (0.67) | LTA4HTSHRSRCMMP2CA9 | |
| Diphenylether SCHEMBL27797017 | 0.97 | LTA4H (0.63) | LTA4HTSHRSRCMMP2CA9 | |
| Diphenylether SCHEMBL27662442 | 0.97 | LTA4H (0.63) | LTA4HTSHRSRCMMP2CA9 | |
| Diphenylether SCHEMBL28278866 | 0.97 | LTA4H (0.63) | LTA4HTSHRSRCMMP2CA9 | |
| Diphenylether SCHEMBL28823973 | 0.91 | LTA4H (0.55) | LTA4HTSHRSRCMMP2CA9 | |
| Diphenylether SCHEMBL28260818 | 0.87 | LTA4H (0.57) | LTA4HTSHRSRCMMP2CA9 | |
| Diphenylether SCHEMBL17801641 | 0.87 | SRC (0.60) | LTA4HTSHRSRCMMP2CA9 | |
| Phosphoric Acid SCHEMBL5518515 | 0.87 | HTT (0.61) | LTA4HTSHRSRCMMP2CA9 | |
| Diphenylether SCHEMBL28520621 | 0.87 | LTA4H (0.50) | LTA4HTSHRSRCMMP2CA9 | |
| SCHEMBL11050917 | 0.84 | MMP2 (0.53) | LTA4HTSHRSRCMMP2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227376-A1 | HIGH MELT FLOW POLYETHERIMIDE-SILOXANE COMPOSITIONS, METHOD OF MANUFACTURE, AND ARTICLES MADE THEREFROM | SABIC Global Technologies B.V. (NL) | 2017-10-11 | — | — | EP | claimed |
| WO-2016089583-A1 | HIGH MELT FLOW POLYETHERIMIDE-SILOXANE COMPOSITIONS, METHOD OF MANUFACTURE, AND ARTICLES MADE THEREFROM | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2016-06-09 | — | — | WO | claimed |