SCHEMBL28824705

SCHEMBL28824705

O=C(C#Cc1ccc(F)cc1)Cc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 3/20 0.50
ALDH1A1 P00352 5/20 0.47
RAB9A P51151 2/20 0.47
CNR2 P34972 1/20 0.45
MMP2 P08253 1/20 0.44
MMP9 P14780 1/20 0.44
MMP12 P39900 1/20 0.44
KDM4E B2RXH2 1/20 0.43
CES1 P23141 2/20 0.42
CES2 O00748 1/20 0.42
AKR1B1 P15121 1/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
LMNA P02545 1/20 0.42
MAPK1 P28482 1/20 0.42
CASP3 P42574 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NPC1 O15118 1/20 0.41
HSP90AA1 P07900 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28704538 0.93 FFAR1 (0.54) FFAR1ALDH1A1RAB9ACNR2MMP2
SCHEMBL28479005 0.88 FFAR1 (0.58) FFAR1RAB9ACES1CES2AKR1B1
SCHEMBL28480057 0.83 L3MBTL1 (0.57) FFAR1ALDH1A1RAB9ACNR2KDM4E
SCHEMBL28470683 0.83 VCP (0.54) FFAR1ALDH1A1RAB9ACNR2CES1
SCHEMBL28754059 0.80 RAB9A (0.54) FFAR1ALDH1A1RAB9ACNR2MMP2
SCHEMBL28704543 0.77 VCP (0.58) FFAR1RAB9ACNR2L3MBTL1SMN1; SMN2
SCHEMBL28685979 0.77 FFAR1 (0.54) FFAR1ALDH1A1RAB9ACNR2KDM4E
SCHEMBL28689949 0.77 FFAR1 (0.54) FFAR1ALDH1A1RAB9ACNR2L3MBTL1
SCHEMBL28606843 0.74 FFAR1 (0.54) FFAR1KDM4ELMNASMN1; SMN2
SCHEMBL4174394 0.74 RAB9A (0.58) FFAR1ALDH1A1RAB9AKDM4EL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117586218-A Chiral octacyclic ether compound and synthetic method and application thereof 浙江工业大学 2024-02-23 CN disclosed
CN-110183397-B Method for preparing 1, 5-benzothiazine compound by catalysis of zirconocene dichloride 陕西师范大学 2022-08-23 CN disclosed
CN-110698426-B Method for preparing 1, 3-benzothiazole derivative by efficient catalysis of potassium tert-butoxide 陕西师范大学 2022-08-23 CN disclosed
CN-110698426-A Method for preparing 1, 3-benzothiazole derivative by efficient catalysis of potassium tert-butoxide 陕西师范大学 2020-01-17 CN disclosed