Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 13/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 12/20 | 0.44 |
| ▸ | RXRA | P19793 | 10/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825512 | 0.85 | GRIN1 (0.42) | GRIN2BGRIN1RXRAPOLBMAPT | |
| SCHEMBL28825527 | 0.85 | GRIN2B (0.44) | GRIN2BGRIN1RXRACYP1A2CYP3A4 | |
| SCHEMBL28825583 | 0.83 | GRIN2B (0.44) | GRIN2BGRIN1RXRAKCNH2 | |
| SCHEMBL28949605 | 0.82 | GRIN2B (0.42) | GRIN2BGRIN1RXRAKCNH2 | |
| SCHEMBL28825657 | 0.81 | GRIN2B (0.43) | GRIN2BGRIN1RXRAKCNH2 | |
| SCHEMBL28825617 | 0.78 | GRIN2B (0.46) | GRIN2BGRIN1RXRACYP3A4CYP2D6 | |
| SCHEMBL28825437 | 0.77 | GRIN1 (0.44) | GRIN2BGRIN1RXRACYP1A2CYP3A4 | |
| SCHEMBL28825640 | 0.77 | GRIN2B (0.47) | GRIN2BGRIN1RXRAKCNH2 | |
| SCHEMBL10914962 | 0.71 | ALDH1A1 (0.57) | MAPTLMNACYP1A2CYP2D6 | |
| SCHEMBL30029575 | 0.71 | ALDH1A1 (0.57) | MAPTLMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |