Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 7/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.33 |
| ▸ | RXRA | P19793 | 5/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825671 | 0.84 | GRIN1 (0.45) | GRIN1GRIN2BALOX5APFEN1NFE2L2 | |
| SCHEMBL28825503 | 0.72 | MEN1 (0.41) | GRIN1GRIN2BNFE2L2RXRA | |
| SCHEMBL12094716 | 0.71 | APLNR (0.43) | GRIN1GRIN2BALOX5APFEN1SOS1 | |
| SCHEMBL30864870 | 0.71 | APLNR (0.43) | GRIN1GRIN2BALOX5APFEN1SOS1 | |
| SCHEMBL28825599 | 0.71 | GRIN1 (0.46) | GRIN1GRIN2BIDH1RXRA | |
| SCHEMBL28825611 | 0.71 | GRIN1 (0.43) | GRIN1GRIN2BRXRA | |
| SCHEMBL28825666 | 0.69 | GRIN1 (0.41) | GRIN1GRIN2BRXRARELA | |
| SCHEMBL28825504 | 0.69 | ALOX5 (0.42) | GRIN1GRIN2BNFE2L2 | |
| SCHEMBL23516654 | 0.68 | IDH1 (0.44) | IDH1NFE2L2APLNR | |
| SCHEMBL28151579 | 0.68 | IDH1 (0.44) | ALOX5APFEN1IDH1NFE2L2APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |