Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | RXRA | P19793 | 4/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825645 | 0.83 | RAB9A (0.47) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL28825500 | 0.80 | RAB9A (0.40) | RAB9AKMT2AGRIN1GRIN2B | |
| SCHEMBL28825536 | 0.80 | GRIN2B (0.37) | GRIN1GRIN2BRXRA | |
| SCHEMBL28825471 | 0.80 | GRIN1 (0.38) | GRIN1GRIN2B | |
| SCHEMBL28825467 | 0.80 | GRIN1 (0.42) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL28517481 | 0.79 | PTGS1 (0.50) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL28825433 | 0.76 | NPC1 (0.42) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL28825496 | 0.74 | RAB9A (0.52) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL28825528 | 0.73 | NPC1 (0.53) | MEN1NPC1RAB9AKMT2AATM | |
| SCHEMBL28825504 | 0.72 | ALOX5 (0.42) | NPC1RAB9AGRIN1GRIN2BNFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-114007610-A | Substituted heteroaromatic pyrazolopyridines and their use as modulators of the GLUN2B receptor | 詹森药业有限公司 | 2022-02-01 | — | — | CN | disclosed |