Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | NGFR | P08138 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28049574 | 0.84 | GAA (0.52) | MAPTNPC1KMT2ARAB9AMEN1 | |
| SCHEMBL28211409 | 0.82 | NTRK1 (0.56) | NTRK1NGFRMAPTPOLBEGFR | |
| SCHEMBL19086870 | 0.81 | NPC1 (0.53) | NTRK1NGFRMAPTPOLBEGFR | |
| SCHEMBL7975873 | 0.80 | MAPT (0.52) | NTRK1NGFRMAPTPOLBEGFR | |
| SCHEMBL28211430 | 0.80 | NTRK1 (0.54) | NTRK1NGFRMAPTPOLBEGFR | |
| SCHEMBL6581634 | 0.78 | ALDH1A1 (0.54) | MAPTTP53NPC1RAB9AALDH1A1 | |
| SCHEMBL6578990 | 0.77 | ALDH1A1 (0.64) | NPC1KMT2ARAB9AMEN1ALDH1A1 | |
| SCHEMBL17578567 | 0.77 | HIF1A (0.67) | NPC1KMT2ARAB9AMEN1 | |
| SCHEMBL7998977 | 0.76 | TP53 (0.46) | NTRK1NGFRMAPTPOLBSRC | |
| SCHEMBL7997564 | 0.75 | TP53 (0.50) | MAPTPOLBTP53NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384687-A | Quinolinone compound and application thereof in drugs | GUANGDONG HEC PHARMACEUTICAL | 2016-03-09 | — | — | CN | disclosed |