Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28059288 | 0.93 | OPRK1 (0.38) | POLBCHRNB2CHRNA4CPT1AOPRK1 | |
| SCHEMBL28059300 | 0.86 | CHRM3 (0.38) | POLBCHRNB2CHRNA4OPRK1KCNH2 | |
| SCHEMBL20658831 | 0.77 | TSHR (0.38) | POLBOPRK1KCNH2CHRM3ALDH1A1 | |
| SCHEMBL28053867 | 0.76 | OPRK1 (0.41) | POLBOPRK1KCNH2CHRM3 | |
| SCHEMBL4279118 | 0.76 | CHRM3 (0.36) | OPRK1KCNH2CHRM3 | |
| SCHEMBL4279130 | 0.76 | CHRM3 (0.36) | OPRK1KCNH2CHRM3 | |
| SCHEMBL28059315 | 0.76 | SLC6A2 (0.44) | CHRNB2CHRNA4CPT1AALDH1A1LTA4H | |
| SCHEMBL23582990 | 0.73 | RIPK1 (0.38) | ALDH1A1RIPK1LMNADPP4DPP8 | |
| SCHEMBL23582028 | 0.73 | TSHR (0.48) | — | |
| SCHEMBL23526972 | 0.70 | EPHX2 (0.42) | ALDH1A1LMNANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384695-A | Pyrimidine derivative, preparation method therefor and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |