Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 7/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28053866 | 0.84 | SLC6A2 (0.50) | OPRK1KCNH2CHRM3 | |
| SCHEMBL4718944 | 0.81 | HRH1 (0.47) | KCNH2 | |
| SCHEMBL15639975 | 0.80 | CHRM3 (0.34) | OPRK1KCNH2CHRM3POLBEPHX2 | |
| SCHEMBL28059288 | 0.80 | OPRK1 (0.38) | OPRK1KCNH2CHRM3POLBCHRM2 | |
| SCHEMBL8536867 | 0.80 | CCR5 (0.40) | CHRM3POLBCHRM2EPHX2 | |
| SCHEMBL2196095 | 0.79 | OPRK1 (0.39) | OPRK1KCNH2OPRM1 | |
| SCHEMBL3985447 | 0.79 | RIPK1 (0.39) | OPRM1 | |
| SCHEMBL3292130 | 0.79 | OPRK1 (0.49) | OPRK1CHRM3EPHX2 | |
| SCHEMBL4469103 | 0.78 | HMOX1 (0.36) | CHRM3CHRM2EPHX2 | |
| SCHEMBL10262344 | 0.77 | KDM1A (0.42) | OPRK1KCNH2CHRM3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105384694-A | Substituted aminopyrimidine derivative, preparation method therefor and pharmaceutical application thereof | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |
| CN-105384695-A | Pyrimidine derivative, preparation method therefor and application thereof in medicine | SICHUAN HAISCO PHARMACEUTICAL CO LTD | 2016-03-09 | — | — | CN | disclosed |