Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18562094 | 0.88 | POLB (0.50) | LMNAPOLBALDH1A1ATMMAPT | |
| SCHEMBL7987260 | 0.77 | KDM4E (0.37) | LMNAPOLBALDH1A1HDAC3HDAC1 | |
| SCHEMBL9818953 | 0.63 | POLB (0.46) | LMNAPOLBALDH1A1ATMMAPT | |
| SCHEMBL11668837 | 0.58 | ALDH1A1 (0.41) | LMNAPOLBALDH1A1HDAC3HDAC1 | |
| SCHEMBL4346796 | 0.57 | — | — | |
| SCHEMBL7983926 | 0.56 | FFAR1 (0.69) | LMNAPOLBALDH1A1MAPTSMN1; SMN2 | |
| Tiazotic Acid SCHEMBL6409061 | 0.54 | POLB (0.51) | LMNAPOLBALDH1A1ATMMAPT | |
| SCHEMBL10564208 | 0.54 | HDAC3 (0.41) | LMNAPOLBHDAC3HDAC1HDAC2 | |
| SCHEMBL31514850 | 0.53 | NPSR1 (0.35) | LMNAALDH1A1MAPTNPSR1SMN1; SMN2 | |
| SCHEMBL1323505 | 0.53 | CYP2D6 (0.67) | POLBALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105601649-A | Thiazolo[3,2-b]-1,2,4-triazine-3-acetic acid derivative and application thereof | UNIV SHENYANG PHARMACEUTICAL | 2016-05-25 | — | — | CN | disclosed |