Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | PRNP | P04156 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856477 | 0.82 | EGFR (0.39) | DRD4DRD3L3MBTL1PIK3CDALDH1A1 | |
| Ethoxycarbonyl Group SCHEMBL28040923 | 0.74 | ELANE (0.37) | L3MBTL1KMT2AMEN1MAPTKDM4E | |
| Ethoxycarbonyl Group SCHEMBL28040581 | 0.74 | ELANE (0.37) | KMT2AMAPTKDM4EALDH1A1CYP1A2 | |
| Ethoxycarbonyl Group SCHEMBL28094500 | 0.73 | ALDH1A1 (0.39) | L3MBTL1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL2919205 | 0.71 | SYK (0.40) | DRD4DRD3KMT2AMEN1SYK | |
| Ethoxycarbonyl Group SCHEMBL27414264 | 0.71 | MAPT (0.40) | KMT2AMAPTKDM4ECYP1A2HPGD | |
| O-Xylene SCHEMBL27642057 | 0.70 | TSHR (0.46) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| O-Xylene SCHEMBL27858274 | 0.69 | TSHR (0.40) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| Ethoxycarbonyl Group SCHEMBL28048074 | 0.69 | ADRA2A (0.32) | L3MBTL1KDM4E | |
| Ethoxycarbonyl Group SCHEMBL28020917 | 0.69 | DGAT1 (0.32) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105601619-A | JAK kinase modulating compounds and methods of use thereof | AMBIT BIOSCIENCES CORP | 2016-05-25 | — | — | CN | disclosed |