Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3298816 | 0.77 | LCK (0.36) | CYP1A2CYP2C9CYP2C19KDM4EGPR55 | |
| SCHEMBL10147161 | 0.68 | CYP19A1 (0.42) | KCNH2CYP11B1CYP11B2DYRK1A | |
| SCHEMBL10013033 | 0.63 | ALDH1A1 (0.38) | KDM4EHSD11B1KMT2ALMNAHTT | |
| SCHEMBL996357 | 0.63 | CACNA1B (0.46) | CACNA1BKCNH2CYP1A2 | |
| SCHEMBL10989241 | 0.61 | IDO1 (0.45) | KCNH2CYP11B1CYP11B2DYRK1AIDO1 | |
| SCHEMBL13059068 | 0.60 | POLB (0.35) | KCNH2CYP11B1CYP11B2DYRK1A | |
| SCHEMBL1948994 | 0.60 | CYP11B1 (0.60) | KCNH2CYP11B1CYP11B2DYRK1ALMNA | |
| SCHEMBL11385165 | 0.60 | RAB9A (0.47) | CYP1A2CYP2C9CYP2C19KDM4EHSD11B1 | |
| SCHEMBL25212373 | 0.60 | POLB (0.37) | KCNH2DYRK1A | |
| SCHEMBL21558234 | 0.60 | POLB (0.37) | KCNH2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2010521468-A | — | — | 2010-06-24 | — | — | JP | claimed |
| EP-2134854-A1 | TREATMENT METHOD USING EGFR ANTIBODIES AND SRC INHIBITORS AND RELATED FORMULATIONS | LUDWIG INSTITUTE FOR CANCER RESEARCH (US) | 2009-12-23 | — | — | EP | claimed |
| WO-2008115404-A1 | TREATMENT METHOD USING EGFR ANTIBODIES AND SRC INHIBITORS AND RELATED FORMULATIONS | LUDWING INSTITUTE FOR CANCER RESEARCH (US) | 2008-09-25 | — | — | WO | claimed |