SCHEMBL28833252

SCHEMBL28833252

COCOc1ccc(C#N)cc1B1OCCCC(C)(C)C(C)(C)O1

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28833338 0.83 TRPV4 (0.34) USP2MAPT
SCHEMBL1303775 0.75 RARG (0.33)
SCHEMBL29447080 0.74 TRPV4 (0.36) USP2MAPT
SCHEMBL22323989 0.74 TRPV4 (0.36) USP2MAPT
SCHEMBL1303773 0.73 TRPV4 (0.30)
SCHEMBL30526793 0.71 TRPV4 (0.47) USP2MAPT
SCHEMBL1303766 0.70 AR (0.42) USP2MAPT
SCHEMBL30083309 0.70 AR (0.42) USP2MAPT
SCHEMBL28691150 0.69 TRPV4 (0.33)
SCHEMBL22320285 0.66 ACHE (0.33) USP2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114981251-A Diphenyl furan derivative cathepsin K inhibitor and preparation method and medical application thereof 深圳信立泰药业股份有限公司 2022-08-30 CN disclosed