Sugi Predict

Sugi Predict / Compounds / SCHEMBL2884078

SCHEMBL2884078

SCHEMBL2884078

Cc1cc(Cn2nc(C(F)(F)C(F)(F)CF)cc2C(F)(F)C(F)(F)CF)ccc1N

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIA2 P42262 1/20 0.35
▸ SKP2 Q13309 1/20 0.34
▸ ADORA3 P0DMS8 1/20 0.34
▸ ADORA2A P29274 1/20 0.34
▸ ADORA2B P29275 1/20 0.34
▸ ADORA1 P30542 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.32
▸ HDAC3 O15379 2/20 0.32
▸ HDAC4 P56524 2/20 0.32
▸ HDAC1 Q13547 2/20 0.32
▸ HDAC7 Q8WUI4 2/20 0.32
▸ HDAC2 Q92769 2/20 0.32
▸ HDAC10 Q969S8 2/20 0.32
▸ HDAC11 Q96DB2 2/20 0.32
▸ HDAC8 Q9BY41 2/20 0.32
▸ HDAC6 Q9UBN7 2/20 0.32
▸ HDAC9 Q9UKV0 2/20 0.32
▸ HDAC5 Q9UQL6 2/20 0.32
▸ NCOR2 Q9Y618 2/20 0.32
▸ POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2889650 0.86 SKP2 (0.36) GRIA2SKP2ADORA3ADORA2AADORA2B
SCHEMBL2161565 0.83 GRIA2 (0.41) GRIA2SKP2ADORA3ADORA2AADORA2B
SCHEMBL1831039 0.81 GRIA2 (0.47) GRIA2SKP2ADORA3ADORA2AADORA2B
SCHEMBL2884082 0.77 SKP2 (0.35) GRIA2SKP2ADORA3ADORA2AADORA2B
SCHEMBL12402161 0.75 HPGD (0.46) SKP2ALDH1A1HDAC3HDAC4HDAC1
SCHEMBL2889517 0.73 KLKB1 (0.35) GRIA2SKP2KLKB1
SCHEMBL1832434 0.73 ADORA3 (0.33) SKP2ADORA3ADORA2AADORA2BADORA1
SCHEMBL1834782 0.72 SLC2A1 (0.32) GRIA2HDAC3HDAC4HDAC1HDAC7
SCHEMBL1833650 0.71 ALDH1A1 (0.42) ADORA3ADORA2AADORA2BADORA1ALDH1A1
SCHEMBL1833387 0.71 ADORA3 (0.32) SKP2ADORA3ADORA2AADORA2BADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100130743-A1 HETEROCYCLE-SUBSTITUTED, N-PHENYL-PHTHALAMIDE DERIVATIVES, RELATED COMPOUNDS AND THEIR USE AS INSECTICIDES BAYER CROPSCIENCE AG (DE) 2010-05-27 — — US disclosed
US-7674807-B2 Heterocycle-substituted n-phenyl-phthalamide derivatives, related compounds and their use as insecticides BAYER CROPSCIENCE AG (DE) 2010-03-09 — — US disclosed
US-20070299085-A1 N1-((Pyrazol-1-Ymethyl)-2-Methylphenyl)-Phatalamide Derivatives And Related Compounds Insecticides BAYER CROPSCIENCE AG (DE) 2007-12-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100130743-A1 HETEROCYCLE-SUBSTITUTED, N-PHENYL-PHTHALAMIDE DERIVATIVES, RELATED COMPOUNDS AND THEIR USE AS INSECTICIDES DDT, SQOR, CYP2S1 GRIA2 4434/4885SKP2 1205/4885ADORA3 3609/4885
US-20070299085-A1 N1-((Pyrazol-1-Ymethyl)-2-Methylphenyl)-Phatalamide Derivatives And Related Compounds Insecticides CHRM1, KCNH1, DDT GRIA2 4212/4885SKP2 1596/4885ADORA3 1259/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.