Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | BCR | P11274 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | PRKACA | P17612 | 2/20 | 0.44 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.44 |
| ▸ | PRKACG | P22612 | 1/20 | 0.44 |
| ▸ | PRKACB | P22694 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28145444 | 0.79 | PLK1 (0.48) | PLK1MEN1KMT2ARAB9AABL1 | |
| SCHEMBL7232176 | 0.78 | ALDH1A1 (0.57) | PLK1NPC1RAB9AALDH1A1LMNA | |
| SCHEMBL4708076 | 0.76 | HSP90AA1 (0.67) | PLK1CAMK2DMEN1KMT2ANPC1 | |
| SCHEMBL4734426 | 0.76 | PLK1 (0.80) | PLK1CAMK2DMEN1KMT2ANPC1 | |
| SCHEMBL4734622 | 0.75 | ABL1 (0.76) | PLK1CAMK2DMEN1KMT2ANPC1 | |
| SCHEMBL4706796 | 0.73 | PLK1 (0.61) | PLK1NPC1RAB9ACDK5CDK5R1 | |
| SCHEMBL1466904 | 0.73 | CAMK2D (0.58) | PLK1CAMK2DMEN1KMT2ANPC1 | |
| SCHEMBL627394 | 0.73 | KARS1 (0.56) | PLK1CAMK2DMEN1KMT2ANPC1 | |
| SCHEMBL12171957 | 0.72 | MEN1 (0.64) | PLK1CAMK2DMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL4630422 | 0.72 | KARS1 (0.55) | PLK1CAMK2DMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106674197-A | Aurora kinase A inhibitor and preparation and application thereof | 兰州大学 | 2017-05-17 | — | — | CN | disclosed |