Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.35 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25180819 | 0.85 | CASP6 (0.36) | FAAHCASP6HTR2CHDAC4GABRG2 | |
| SCHEMBL28211033 | 0.84 | GABRG2 (0.47) | CASP6HDAC4GABRG2GABRB3GABRA5 | |
| SCHEMBL34461976 | 0.84 | GABRG2 (0.47) | CASP6HDAC4GABRG2GABRB3GABRA5 | |
| SCHEMBL23499270 | 0.78 | CASP6 (0.40) | FAAHCASP6HTR2CHDAC4GABRG2 | |
| SCHEMBL16711570 | 0.78 | GABRG2 (0.43) | CASP6HTR2CHDAC4GABRG2GABRB3 | |
| SCHEMBL1248582 | 0.77 | FAAH (0.33) | FAAH | |
| SCHEMBL30888806 | 0.74 | KDM4E (0.50) | MAPK1 | |
| SCHEMBL970044 | 0.74 | KDM4E (0.50) | MAPK1 | |
| SCHEMBL24352491 | 0.74 | CASP6 (0.41) | CASP6HTR2CHDAC4GABRG2GABRB3 | |
| SCHEMBL29986122 | 0.73 | KDM4E (0.48) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103002897-B | Certain amino-pyridazines, compositions thereof, and methods of use thereof | 赛特凯恩蒂克公司 | 2017-06-09 | — | — | CN | claimed |