Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | CREB1 | P16220 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 3/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29195654 | 0.90 | ACHE (0.46) | ACHEBCHEMAPTABCB1PLK1 | |
| SCHEMBL28848659 | 0.85 | ACHE (0.67) | ACHEBCHEMAPTABCB1PLK1 | |
| SCHEMBL28848526 | 0.82 | ACHE (0.60) | ACHEBCHEMAPTABCB1PLK1 | |
| SCHEMBL28848656 | 0.82 | ACHE (0.51) | ACHEBCHEMAPTABCB1PLK1 | |
| SCHEMBL28848654 | 0.80 | KDM5A (0.52) | ACHEBCHEMAPTABCB1PLK1 | |
| SCHEMBL28848517 | 0.79 | ACHE (0.49) | ACHEBCHEMAPTABCB1PLK1 | |
| SCHEMBL21335354 | 0.77 | ACHE (0.77) | ACHEBCHEMAPTABCB1PLK1 | |
| SCHEMBL28848525 | 0.77 | USP8 (0.60) | ACHEBCHEMAPTABCB1PLK1 | |
| SCHEMBL28848489 | 0.77 | CDK9 (0.55) | ACHEBCHEMAPTABCB1PLK1 | |
| SCHEMBL25301059 | 0.75 | ABCB1 (0.65) | ACHEBCHEMAPTABCB1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114957182-A | USP8 inhibitor containing flavone skeleton structure and application thereof | 中国药科大学 | 2022-08-30 | — | — | CN | disclosed |